The Condello lab innovates new imaging methods and model systems to elucidate the cell and molecular biology of Alzheimer’s disease and related neurodegenerative disorders. We aim to understand the dynamic role of glial cells, in particular microglia and innate immune function, and their functional interactions with healthy and degenerating neurons. In tandem, we study genetic risk factors and human biology of disease using patient samples to inform and validate discoveries made in model systems. To reveal biological mechanisms of protein aggregation, cell death and innate immunity, we employ an interdisciplinary approach including cell and molecular neuroscience, biophysics, chemical biology and advanced optical imaging methods.
News
- March, 2023: New paper published in PNAS: EMBER multidimensional spectral microscopy enables quantitative determination of disease- and cell-specific amyloid strains
- January, 2023: New paper published in Nature Communications: CSF1R inhibitors induce a sex-specific resilient microglial phenotype and functional rescue in a tauopathy mouse model
- December, 2022: Carlo Condello awarded New Frontiers Research Award from Program for Breakthrough Biomedical Research (PBBR) at UCSF
- November, 2022: New paper published in PNAS: Aβ and tau prions feature in the neuropathogenesis of Down syndrome
- July, 2022: Welcome to our newest graduate student, Stephanie Huard!
- May, 2022: Carlo Condello named The Edward N. & Della L. Thome Memorial Foundation Awards Program in Alzheimer's Disease Drug Discovery Research 2021 Award Recipient
- December 2021: New paper published in Acta Neuropathologica Communications: Emergence of distinct and heterogeneous strains of amyloid beta with advanced Alzheimer’s disease pathology in Down syndrome
- October, 2021: Hyunjun Yang receives Program for Breakthrough Biomedical Research Postdoctoral Independent Research Grant
- September, 2021: Welcome to our newest research assistant, Marie Shi!
- August, 2021: Carlo Condello receives the Ludwig Family Foundation Early Career Award
- July, 2021: New manuscript posted on BioRxiv: Emergence of distinct and heterogeneous strains of amyloid beta as Alzheimer’s disease progresses in Down syndrome
- July, 2021: Carlo Condello receives John A. Watson Faculty Scholar Award (UCSF School of Medicine, Dean's Diversity Fund)
- June, 2021: Best of luck to lab member Madhy Garcia on her graduate school journey at the University of California, Irvine!
- June, 2021: Welcome to our newest graduate student, Ian Steele!
- May, 2021: Welcome to our newest postdoctoral fellow, Erika Castillo!
- March, 2021: New manuscript posted on BioRxiv: CSF1R inhibitor levels determine sex-specific phenotype of resilient microglia and neurofunctional rescue leading to extended survival in tauopathy mice
- October, 2020: Hyunjun Yang awarded Bright Focus Postdoc Fellowship.