The Condello lab innovates new imaging methods and model systems to elucidate the cell and molecular biology of Alzheimer’s disease and related neurodegenerative disorders. We aim to understand the dynamic role of glial cells, in particular microglia and innate immune function, and their functional interactions with healthy and degenerating neurons. In tandem, we study genetic risk factors and human biology of disease using patient samples to inform and validate discoveries made in model systems. To reveal biological mechanisms of protein aggregation, cell death and innate immunity, we employ an interdisciplinary approach including cell and molecular neuroscience, biophysics, chemical biology and advanced optical imaging methods.
News
- Welcome to our newest research assistant, Marie Shi!
- Carlo Condello receives the Ludwig Family Foundation Early Career Award
- New manuscript posted on BioRxiv: Emergence of distinct and heterogeneous strains of amyloid beta as Alzheimer’s disease progresses in Down syndrome
- Carlo Condello receives John A. Watson Faculty Scholar Award (UCSF School of Medicine, Dean's Diversity Fund)
- Hyunjun-Yang receives Program for Breakthrough Biomedical Research Postdoctoral Independent Research Grant
- Best of luck to lab member Madhy Garcia on her graduate school journey at the University of California, Irvine!
- Welcome to our newest graduate student, Ian Steele!
- Welcome to our newest postdoctoral fellow, Erika Castillo!
- New manuscript posted on BioRxiv: Sex-specific life extension in tauopathy mice by CSF1R inhibition causing selective microglial depletion and suppressed pathogenesis