Selected Publications

(Click here for all publications) 

  1. Roles of microglia in tauopathy-mediated neurodegeneration

    CSF1R inhibitors induce a sex-specific resilient microglial phenotype and functional rescue in a tauopathy mouse model
    Johnson N, Yuan P, Castillo E, Lopez P, Yue W, Bond A, Rivera BR, Sullivan M, Hirouchi M, Giles K, Aoyagi A, Condello C
    Nature Communications. 2023 January 9 https://doi.org/10.1038/s41467-022-35753-w

    Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy
    Wang C, Fan L, Zhan L, Kodama L, Liu B, Chin M, Li Y, Le D, Zhou Y, Condello C, Grinberg L, Seeley WW, Miller B, Mok SA, Gestwicki J, Gan L
    Nature Communications. 2022 April 12 https://doi.org/10.1038/s41467-022-29552-6

  2. Kinetics, toxicity and conformational heterogeneity of amyloid deposition:   

    Cryo-EM structures reveal tau filaments from Down syndrome adopt Alzheimer’s disease fold
    Ujjayini Ghosh, Eric Tse, Hyunjun Yang*, Marie Shi*, Christofer D. Caro*, Feng Wang, Gregory E. Merz, Stanley B. Prusiner, Daniel R. Southworth, and Carlo Condello*
    Acta Neuropathol Commun. 2024 Jun 12; PMID: 38867338 https://doi.org/10.1186/s40478-024-01806-y

    ​EMBER multidimensional spectral microscopy enables quantitative determination of disease- and cell-specific amyloid strains
    Yang H*, Yuan P, Wu Y, Shi M*, Caro CD, Tengeiji A,  Yamanoi S, Inoue M, DeGrado WF, Condello C
    Proc Natl Acad Sci U S A. 2023 Mar 16; PMID: 36778268  https://doi.org/10.1073/pnas.2300769120

    Emergence of distinct and heterogeneous strains of amyloid beta with advanced Alzheimer’s disease pathology in Down syndrome
    Maxwell AM*, Yuan P, Rivera BR*, Schaaf W, Mladinov M, Prasher VP, Robinson AC, DeGrado WF, Condello C 
    Acta Neuropathol Commun. 2021 Dec 27; PMID: 34961556  https://doi.org/10.1186/s40478-021-01298-0

    Structural heterogeneity and inter-subject variability of Aβ in familial and sporadic Alzheimer’s disease.
    Condello C*, Lemmin T*, Stöhr J*, Nick M, Wu Y, Maxwell AM, Watts JC, Caro CD, Oehler A, Keene CD, Bird TD, van Duinen SG, Lannfelt L, Ingelsson M, Graff C, Giles K, DeGrado WF, Prusiner SB.
    Proc Natl Acad Sci U S A. 2018 Jan 8 PMID: 29311311. 
    PubMed doi pdf

    Multicolor time-stamp reveals the dynamics and toxicity of amyloid deposition.
    Condello C, Schain A, Grutzendler J.
    Sci Rep. 2011; 1:19. PMID: 22355538.
    doi pdf

  3. Neuroprotective roles of microglia in Alzheimer’s disease: 

    Microglia-mediated neuroprotection, TREM2 and Alzheimer’s disease: Evidence from optical imaging.
    Condello C, Yuan P, Grutzendler J.
    Biological Psychiatry. 2017 Oct 17 PMID: 29169609. 
    PubMed doi

    TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy.
    Yuan P*, Condello C*, Keene CD, Wang Y, Bird TD, Paul SM, Luo W, Colonna M, Baddeley D, Grutzendler J.  
    Neuron. 2016 May 18; 90(4):724-739. PMID: 27196974.
    PubMed doi pdf

    Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques.
    Condello C*, Yuan P*, Schain A, Grutzendler J.
    Nature Commun. 2015; 6:6176. PMID: 25630253.
    PubMed doi pdf

    CX3CR1 in microglia regulates brain amyloid deposition through selective protofibrillar amyloid-ß phagocytosis.
    Liu Z*, Condello C*, Schain A, Harb R, Grutzendler J.
    J Neurosci. 2010 Dec 15; 30(50):17091-101. PMID: 21159979.
    PubMed doi pdf

  4. Molecular factors regulating the propagation of pathogenic tau:   

    CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis
    Avi J. Samelson, Nabeela Ariqat, Justin McKetney, Gita Rohanitazangi, Celeste Parra Bravo, Darrin Goodness, Ruilin Tian,
    Parker Grosjean, Romany Abskharon, David Eisenberg, Nicholas M. Kanaan, Li Gan, Carlo Condello, Danielle L. Swaney, Martin Kampmann
    Preprint. 2023 Jun 26. doi: https://doi.org/10.1101/2023.06.16.545386
    BioRxiv

    Mapping Interactions with the Chaperone Network Reveals Factors that Protect Against Tau Aggregation.
    Mok SA, Condello C, Freilich R, Gillies, A, Arhar T, Oroz J, Kadavath H, Julien O, Assimon VA, Rauch JN, Dunyak BM, Lee J, Tsai FTF, Wilson MR, Zweckstetter M, Dickey CA, Gestwicki JE.
    Nature Struct Mol Biol. 2018 Apr 30. PMID: 29728653.
    PubMed doi pdf

    Evidence for sortilin modulating regional accumulation of human tau prions in transgenic mice.
    Johnson N*, Condello C*, Guan S, Oehler A, Becker J, Gavidia M, Carlson GA, Giles K, Prusiner SB.
    Proc Natl Acad Sci U S A. 2017 Dec 4 PMID: 29203673.
    PubMed doi pdf

    A 31-residue peptide induces aggregation of tau’s microtubule-forming region in cells.
    Stöhr J, Nick M, Wu H, Wu Y, Bhate M, Condello C, Johnson N, Rodgers J, Lemmin T, Acharya S, Becker J, Robinson K, Kelly MJ, Gai F, Stubbs G, Prusiner SB, and DeGrado WF.
    Nature Chemistry. 2017 Apr 3. PMID: 28837163.
    PubMed doi pdf

  5. Propagation of Aβ- and tau-prion strains: 

    Severe neurodegeneration in brains of transgenic rats producing human tau prions
    Jacob Ayers, T. Peter Lopez, Ian T. Steele, Abby Oehler, Rigo Roman-Albarran, Elisa Cleveland, Alex Chong, George A. Carlson, Carlo Condello & Stanley B. Prusiner
    Acta Neuropathol 2024 Aug 20;148(1):25. PMID: 39160375; DOI: 10.1007/s00401-024-02771-5

    Expanding the Prion Paradigm to Include Alzheimer and Parkinson Diseases
    Carlo Condello    , David Westaway, Stanley B. Prusiner
    JAMA Neurol. 2024 Aug 19; PMID: 39158847; DOI: 10.1001/jamaneurol.2024.2464

    Guam ALS-PDC is a distinct double-prion disorder featuring both tau and Aβ prions
    Carlo Condello    , Jacob I. Ayers, Clifton L. Dalgard, Madhy Garcia, Brianna M. Rivera, William W. Seeley, Daniel P. Perl, Stanley B. Prusiner
    Proc Natl Acad Sci U S A. 2023 Mar 23; PMID: 36952379
    PubMed doi

    Aβ and tau prions feature in the neuropathogenesis of Down syndrome
    Condello C    , Maxwell AM, Castillo E, Aoyagi A, Graff C, Ingelsson M, Lannfelt L, Bird TD, Keene CD, Seeley WW, Perl DP, Head E, Prusiner SB
    Proc Natl Acad Sci U S A. 2022 Nov 16
    PubMed doi

    Prion biology: implications for Alzheimer's disease therapeutics.
    Condello C, DeGrado WF, Prusiner SB.
    Lancet Neurol. 2020 Oct;19(10):802-803. PMID: 32949533.
    PubMed doi

    Aβ and tau prion-like activities decline with longevity in Alzheimer’s disease human brains.
    Aoyagi A*, Condello C*, Stöhr J, Yue W, Rivera BR, Lee JC, Woerman AW, Halliday G, van Duinen SG, Ingelsson M, Lannfelt L, Graff C, Bird TD, Keene CD, Seeley WW, DeGrado WF, Prusiner SB.
    Sci Transl Med. 2019 May 1; PMID: 31043574. 
    PubMed doi pdf

    Aβ propagation and strains: Implications for the phenotypic diversity in Alzheimer’s disease.
    Condello C and Stöhr J.
    Neurobiol. Dis.2017 March 28. PMID: 28359847.
    PubMed doi

    Serial propagation of distinct strains of Aβ prions from Alzheimer's disease patients.
    Watts JC, Condello C, Stöhr J, Oehler A, Lee J, DeArmond SJ, Lannfelt L, Ingelsson M, Giles K, Prusiner SB.
    Proc Natl Acad Sci U S A. 2014 Jul 15; 111(28):10323-8. PMID: 24982139. 
    PubMed doi pdf

    Distinct synthetic Aβ prion strains producing different amyloid deposits in bigenic mice.
    Stöhr J, Condello C, Watts JC, Bloch L, Oehler A, Nick M, DeArmond SJ, Giles K, DeGrado WF, Prusiner SB.
    Proc Natl Acad Sci U S A. 2014 Jul 15; 111(28):10329-34. PMID: 24982137.
    PubMed doi pdf