Selected Publications

(Click here for all publications) 

  1. Roles of microglia in tauopathy-mediated neurodegeneration

    Sex-specific life extension in tauopathy mice by CSF1R inhibition causing selective microglial depletion and suppressed pathogenesis
    Johnson N, Yuan P, Lopez P, Yue W, Bond A, Rivera BR, Hirouchi M, Giles K, Aoyagi A, Condello C
    bioRxiv 2021.03.20.436288; doi: https://doi.org/10.1101/2021.03.20.436288

    Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy
    Wang C, Fan L, Zhan L, Kodama L, Liu B, Chin M, Li Y, Le D, Zhou Y, Condello C, Grinberg L, Seeley WW, Miller B, Mok SA, Gestwicki J, Gan L
    bioRxiv 2021.02.22.432272; doi: https://doi.org/10.1101/2021.02.22.432272

  2. Kinetics, toxicity and conformational heterogeneity of amyloid deposition:   

    Emergence of distinct and heterogeneous strains of amyloid beta with advanced Alzheimer’s disease pathology in Down syndrome
    Maxwell AM*, Yuan P, Rivera BR*, Schaaf W, Mladinov M, Prasher VP, Robinson AC, DeGrado WF, Condello C 
    Acta Neuropathol Commun. 2021 Dec 27; PMID: 34961556

    Structural heterogeneity and inter-subject variability of Aβ in familial and sporadic Alzheimer’s disease.
    Condello C*, Lemmin T*, Stöhr J*, Nick M, Wu Y, Maxwell AM, Watts JC, Caro CD, Oehler A, Keene CD, Bird TD, van Duinen SG, Lannfelt L, Ingelsson M, Graff C, Giles K, DeGrado WF, Prusiner SB.
    Proc Natl Acad Sci U S A. 2018 Jan 8 PMID: 29311311. 
    PubMed doi pdf

    Multicolor time-stamp reveals the dynamics and toxicity of amyloid deposition.
    Condello C, Schain A, Grutzendler J.
    Sci Rep. 2011; 1:19. PMID: 22355538.
    doi pdf

  3. Neuroprotective roles of microglia in Alzheimer’s disease

    Microglia-mediated neuroprotection, TREM2 and Alzheimer’s disease: Evidence from optical imaging.
    Condello C, Yuan P, Grutzendler J.
    Biological Psychiatry. 2017 Oct 17 PMID: 29169609. 
    PubMed doi

    TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy.
    Yuan P*, Condello C*, Keene CD, Wang Y, Bird TD, Paul SM, Luo W, Colonna M, Baddeley D, Grutzendler J.  
    Neuron. 2016 May 18; 90(4):724-739. PMID: 27196974.
    PubMed doi pdf

    Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques.
    Condello C*, Yuan P*, Schain A, Grutzendler J.
    Nature Commun. 2015; 6:6176. PMID: 25630253.
    PubMed doi pdf

    CX3CR1 in microglia regulates brain amyloid deposition through selective protofibrillar amyloid-ß phagocytosis.
    Liu Z*, Condello C*, Schain A, Harb R, Grutzendler J.
    J Neurosci. 2010 Dec 15; 30(50):17091-101. PMID: 21159979.
    PubMed doi pdf

  4. Propagation of Aβ- and tau-prion strains: 

    Prion biology: implications for Alzheimer's disease therapeutics.
    Condello C, DeGrado WF, Prusiner SB.
    Lancet Neurol. 2020 Oct;19(10):802-803. PMID: 32949533.
    PubMed doi

    Aβ and tau prion-like activities decline with longevity in Alzheimer’s disease human brains.
    Aoyagi A*, Condello C*, Stöhr J, Yue WRivera BR, Lee JC, Woerman AW, Halliday G, van Duinen SG, Ingelsson M, Lannfelt L, Graff C, Bird TD, Keene CD, Seeley WW, DeGrado WF, Prusiner SB.
    Sci Transl Med. 2019 May 1; PMID: 31043574. 
    PubMed doi pdf

    Aβ propagation and strains: Implications for the phenotypic diversity in Alzheimer’s disease.
    Condello C and Stöhr J.
    Neurobiol. Dis.2017 March 28. PMID: 28359847.
    PubMed doi

    Serial propagation of distinct strains of Aβ prions from Alzheimer's disease patients.
    Watts JC, Condello C, Stöhr J, Oehler A, Lee J, DeArmond SJ, Lannfelt L, Ingelsson M, Giles K, Prusiner SB.
    Proc Natl Acad Sci U S A. 2014 Jul 15; 111(28):10323-8. PMID: 24982139. 
    PubMed doi pdf

    Distinct synthetic Aβ prion strains producing different amyloid deposits in bigenic mice.
    Stöhr J, Condello C, Watts JC, Bloch L, Oehler A, Nick M, DeArmond SJ, Giles K, DeGrado WF, Prusiner SB.
    Proc Natl Acad Sci U S A. 2014 Jul 15; 111(28):10329-34. PMID: 24982137.
    PubMed doi pdf
     

  5. Molecular factors regulating the propagation of pathogenic tau:   

    Mapping Interactions with the Chaperone Network Reveals Factors that Protect Against Tau Aggregation.
    Mok SA, Condello C, Freilich R, Gillies, A, Arhar T, Oroz J, Kadavath H, Julien O, Assimon VA, Rauch JN, Dunyak BM, Lee J, Tsai FTF, Wilson MR, Zweckstetter M, Dickey CA, Gestwicki JE.
    Nature Struct Mol Biol. 2018 Apr 30. PMID: 29728653.
    PubMed doi pdf

    Evidence for sortilin modulating regional accumulation of human tau prions in transgenic mice.
    Johnson N*, Condello C*, Guan S, Oehler A, Becker J, Gavidia M, Carlson GA, Giles K, Prusiner SB.
    Proc Natl Acad Sci U S A. 2017 Dec 4 PMID: 29203673.
    PubMed doi pdf

    A 31-residue peptide induces aggregation of tau’s microtubule-forming region in cells.
    Stöhr J, Nick M, Wu H, Wu Y, Bhate M, Condello C, Johnson N, Rodgers J, Lemmin T, Acharya S, Becker J, Robinson K, Kelly MJ, Gai F, Stubbs G, Prusiner SB, and DeGrado WF.
    Nature Chemistry. 2017 Apr 3. PMID: 28837163.
    PubMed doi pdf